Nicole Paulk

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BIOGRAPHY

Nicole Paulk is a dedicated postdoctoral fellow at Stanford University, working in the laboratory of Dr. Mark A. Kay at the Human Gene Therapy Institute. Her research focuses on advancing gene therapy techniques, particularly exploring ways to improve the packaging capacity of adeno-associated viruses (AAV), which are crucial for gene therapy applications. Nicole’s work aims to expand the potential of gene therapy, allowing it to treat a broader range of genetic disorders. Her contributions are particularly significant in the fields of liver biology and regeneration, where she is developing novel strategies to enhance viral gene targeting and therapeutic liver repopulation in vivo. Her passion for translating her research into real-world therapies is evident in her relentless pursuit of innovative solutions to genetic diseases.

Nicole’s journey into the world of scientific research began at Central Washington University, where she earned her Bachelor of Science degree in Medical Microbiology with a minor in Chemistry. During her time at CWU, she engaged in significant research under the mentorship of Dr. Steven Wagner and Dr. Anne Johansen, focusing on topics such as the effects of pesticides on amphibians and the study of atmospheric sulfinic acids. This early exposure to laboratory research sparked her interest in biology and chemistry, laying the groundwork for her future endeavors in the field of gene therapy. Her undergraduate research experience allowed her to develop critical analytical and experimental skills, which she later built upon during her graduate studies.

Nicole continued to expand her expertise at Oregon Health & Science University, where she earned her PhD in Cell & Developmental Biology. During her doctoral studies, she worked in the laboratory of Dr. Markus Grompe at the Oregon Stem Cell Center, where she developed novel strategies to improve viral gene targeting and therapeutic liver repopulation in vivo. This research contributed to a greater understanding of liver development and regeneration, an area of critical importance for treating liver diseases. Nicole’s PhD work was instrumental in advancing gene therapy methods and their potential applications in treating genetic and chronic liver diseases, which would have a profound impact on the future of medical treatments.

After completing her PhD, Nicole transitioned to her current role at Stanford University, where she continues her postdoctoral research in gene therapy. Her current work focuses on expanding the AAV packaging capacity to broaden the therapeutic applications of gene therapy. This research has the potential to improve the delivery of genetic material into cells, a key challenge in the field of gene therapy. Nicole’s work in this area aims to enhance the efficiency and specificity of gene delivery, which is essential for treating a wide range of genetic disorders. Her research could significantly improve the effectiveness of gene therapy, offering hope for patients with previously untreatable conditions.

Beyond her research, Nicole is passionate about advancing the field of translational research, where laboratory discoveries are brought to clinical applications. She is particularly interested in the areas of DNA repair, virology, and liver biology. Nicole’s dedication to her work, combined with her academic and professional background, positions her as an emerging leader in the field of gene therapy. Her research continues to push the boundaries of science, providing innovative solutions to some of the most challenging issues in modern medicine. Through her work, Nicole is not only advancing scientific knowledge but also contributing to the development of therapeutic strategies that could change the lives of many individuals suffering from genetic diseases.

POSITIONS

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